2.1 DEPARTMENT OF EPIDEMIOLOGY ADMINSTRATIVE ORGANIZATIONS Name Title Contact Information Albert Hofman, MD, PhD Department Chair, Stephan B. Kay Family Professor of Public Health 617-432-6477 ahofman@hsph.harvard.edu Deborah Blacker, ScD, MD Deputy Chair, Professor in Epidemiology Blacker@psych.mgh.harvard.edu Other work has included estimating serotype differences in disease severity, documenting serotype replacement in invasive pneumococcal disease globally (here and here) and investigating the extent to which carriage data can be used to predict invasive disease trends (here and here). By Marcello Ferrada de Noli, Swedish professor emeritus of public health sciences esp. Associate Professor of Epidemiology, Harvard T.H. Studies of Streptococcus pneumoniae combine the practical and the population-biological questions, as well as the experimental and quantitative approaches. Harvard T.H. I direct the Center for Communicable Disease Dynamics, a center of excellence funded by the MIDAS pr… He also directs the Center for Communicable Disease Dynamics, a center of excellence funded by the MIDAS program of NIH/NIGMS, and the … Current work in the laboratory focuses on elucidating the function of antiprotein antibody, the consequences of allelic diversity or target loss for bacterial fitness, and corroboration of these findings by comparing measurements of antibodies in human sera (collaboration with David Goldblatt) against pneumococcal genomes from isolates from the same humans at later time points. Associate Professor of Epidemiology. Talia Quandelacy‘s master’s thesis applied this approach to age- and sex-specific risks. Chan School of Public Health’s Nancy Krieger discusses the impact that COVID-19 is having on communities of color. Marc Lipsitch is Professor of Epidemiology and Director of the Center for Communicable Disease Dynamics at the Harvard T.H. Assistant Professor of Epidemiology. Ed Goldstein, who led most of this work, is currently extending it to other outcomes including hospitalization. We have worked on a variety of topics related to drug resistance in bacteria and viruses, with Bruce Levin, Carl Bergstrom, Megan Murray, Ted Cohen, and Matthew Samore as recurring collaborators. Learn more about Dr. Harrison and her work Another problem in the population biology of pneumococci of longstanding interest is antimicrobial resistance. D.Phil., 1995, Zoology, University of Oxford, Photo Credit: Stephanie Mitchell/Harvard University News Office, Copyright © 2020 The President and Fellows of Harvard College, Harvard T.H. Kolokotrones Professor of Biostatistics and Epidemiology Departments of Epidemiology and Biostatistics. Mechanisms of vaccine action. Chan School of Public Health, Master of Science in Computational Biology and Quantitative Genetics- 80 Credits, Master of Science – 42.5 Credit (Academic Year), Master of Science – 42.5 credit (Summer Only), Environmental and Occupational Epidemiology, Genetic Epidemiology and Statistical Genetics, Reproductive, Perinatal, and Pediatric Epidemiology, Department of Epidemiology Coronavirus (COVID-19) Updates and News, Assistant/Associate Professor of Radiation Epidemiology. Dr. Harvey Risch, epidemiology professor at the Yale School of Public Health, joins Laura Ingraham with insight on 'The Ingraham Angle.' Sarah Cobey took on the challenge of trying to explain serotype coexistence. We have also shown, in work led by Yuan Li on a small genome sample that signals of diversifying selection are statistically apparent in proteins targeted by antibodies, and specifically in epitope regions. Thomas D. Cabot Professor of Public Policy and of Epidemiology. Jose Zubizarreta. I tried to reread “La Peste” [“The Plague”], given the subject matter and the way Camus has influenced my thinking ever since my best friend introduced me to his work. Associate Professor of … website. Working with Richard Hatchett and Carter Mecher, we showed that rapid, early nonpharmaceutical interventions in 1918 were associated with diminished spread of influenza. We held an international meeting in 2010  to discuss lessons learned from the 2009 pandemic, resulting in an extensive summary report. Marc Lipsitch is Professor of Epidemiology and Director of the Center for Communicable Disease Dynamics at the Harvard T.H. A series of studies in collaboration with the Malley lab at Boston Children’s Hospital showed that much of the acquired immune response to pneumococcal carriage was antibody-independent, and probably independent of complement but dependent on CD4+, Th17 cells and neutrophils. Caroline Buckee (8:46), associate professor of epidemiology, Department of Epidemiology, Harvard T.H. That work began with a mathematical modeling study motivated by concerns about serotype replacement following the use of serotype-specific conjugate vaccines and with an experimental demonstration in mice that different strains of pneumococcus compete to colonize the upper respiratory tract. website. Applied pneumococcal epidemiology. On questions of countermeasure optimization, we derived conditions for the predispensing of antivirals to high-risk persons to be life-saving and estimated the impact of targeting high-risk persons for vaccination. This discussion has been active since the publication of two papers in 2012 by the Kawaoka and Fouchier laboratories. Other general phenomena of interest include the mechanisms of coexistence of drug-resistant and -susceptible organisms, the role of veterinary antimicrobial use in promoting resistance in human medicine, methods for analysis of antimicrobial resistance data, and the causes of multiple-drug resistance. He discussed the prospects for mitigating a second wave of the COVID-19 pandemic and the potential approaches to faster development of a vaccine, with JAMA Editor-in-Chief Howard Bauchner, MD, on Dr. Bauchner’s … Streptococcus pneumoniae: immune responses and population biology. Director, Institute of Public Health, Charité – Universitätsmedizin Berlin Adjunct Professor of Epidemiology, Harvard Chan School of Public Health. Müge Çevik (21:01), clinical lecturer in infectious diseases and medical virology, Infection and Global Health Division, School of Medicine, University of St Andrews. Quantitative studies considered the impact of antimicrobial use on resistance at the individual level and the interpretation of clinical trial data to assess this impact. Holding a PhD in the History of Science and an SM from the Harvard School of Public Health, her work addresses the culture, politics, and ethics of measurement in public health and community medicine. I direct the Center for Communicable Disease Dynamics, a center of excellence funded by the MIDAS program of NIH/NIGMS. With … I also served on “Team B” for the United States CDC, providing external advice during the pandemic. A longstanding collaboration with Caroline Colijn, Christophe Fraser, Bill Hanage and Ted Cohen continues to explore alternative explanations for the phenomenon. With many collaborators, we were heavily involved in analyzing data and providing advice to public health authorities during the 2009 influenza pandemic. Copyright © 2020 The President and Fellows of Harvard College, Harvard T.H. Work in this area in our laboratory was led by Krzysztof Trzcinski. Antimicrobial resistance. We are currently undertaking sequencing of a comparably-sized collection of pneumococci from Navajo and White Mountain Apache populations in the Southwestern US, in collaboration with Kate O’Brien of the Johns Hopkins Bloomberg School of Public Health. Pandemic preparedness and response. My Reddit AMA on the topic is here. Harvard doctor explains how at-home coronavirus tests work Dr. Michael Mina, a professor of epidemiology at Harvard’s School of Public Health, said testing has been one of … Working Group Lead Michael Mina, M.D., Ph.D Assistant Professor of Epidemiology, HSPH inference of transmission from pathogen sequence data, pathogen genetic distances in transmission networks, limitations and risks of such experiments, ethical aspects and alternative approaches, barriers to achieving the experiments’ claimed public health goals, White House announced a 1-year funding pause, calculations that should enter such an assessment, Cambridge Center for the Study of Existential Risk, Academic Departments, Divisions and Centers, MRSA: We have applied population genetic approaches to show that patient transfer between hospitals, MCMC approaches to analyze household data to assess time-varying infectiousness with SARS (with, Use of temporal variation in risk factors for infectious disease to infer transmission networks. We have also worked on predicting subtype abundance based on models incorporating inter-subtype competitive inhibition. Chan School of Public Health. Jessica Jacobs’ dissertation estimated that ~13% of meningococcal disease in the US was flu-attributable. In the course of studying this question, we realized that our (and others’) earlier mathematical models of serotype coexistence had inadvertently created “coexistence for free” in models by innocuous-seeming mathematical assumptions that corresponded to no known biological mechanism. A more basic question, still unsolved, is why drug-susceptible and -resistant strains of pneumococci coexist at the population level over long periods. analysis of the first 616 isolates from 2001-7 was published in 2013. analysis of gonococci with reduced susceptibility to cefixime in the US. Other work focused on how to define optimal targeting of scarce pandemic control measures, including antivirals and vaccines, by taking advantage of the data that may be available early in a pandemic (with Jacco Wallinga) or based on a transmission matrix (with Ed Goldstein and with Stephen Eubank’s group at Virginia Tech) or during the declining phase of an epidemic. Harvard epidemiology professor Marc Lipsitch says that the coronavirus will not be containable and that 40-70 of people worldwide will be infected. Chan School of Public Health. Much of this work has been led by Daniel Weinberger, first while he was in our group and recently while he is on the faculty at Yale. Additionally, collaborating with colleagues at the CDC’s Active Bacterial Core surveillance, we have assessed trends in resistance at the national level and partitioned these into effects of changing serotype distribution and changing resistance within serotype, both before and since the introduction of conjugate vaccines. With Megan Murray, James Robins and several other collaborators we made one of the earliest estimates of the reproductive number of the SARS virus during the spring of 2003, and later applied the same approaches to estimate the reproductive number of pandemic influenza in fall, 1918, showing it was around 2. Advertisement - story continues below. Emily Harrison is a Postdoctoral Fellow in Epidemiology and the History of Science at Harvard University. Chan School of Public Health. Chan School of Public Health Presented jointly by The Forum at the Harvard T.H. This has developed into systematic efforts at influenza forecasting centered in the Shaman Lab, which has taken leadership of this strand of research and which won the first CDC flu forecasting competition. Karen Huang’s master’s thesis estimated a ~20% increase in the reproductive number of pandemic flu when schools opened in fall, 2009. Sequence analysis of isolates from later years is ongoing, involving the same team. Pneumococcal population genomics and protein diversity. Bill Hanage is an active collaborator on this project. Research Interests: Causal inference Design and analysis of experiments Design and analysis of observational studies Health outcomes research Public policy. The Department of Epidemiology is currently seeking candidates for the position of Assistant/Associate Professor of Radiation Epidemiology and the position of Assistant or Associate Professor of Epidemiology. I’ve not had time to read anything non-COVID since February. He is an author of more than 250 peer-reviewed publications on antimicrobial resistance, epidemiologic methods, mathematical modeling of infectious disease transmission, pathogen population genomics, and immunoepidemiology of … When we use mathematical models to scale up vaccine effects on the individual to predict effects at the population level, we make strong assumptions about the how the vaccine alters an individual’s risk of infection over multiple exposures. Scale up “the production of … A longstanding collaboration with the George Seage and the CEPAC group at Massachusetts General Hospital (Ken Freedberg, PI) has led to a series of projects using an individual-based model of HIV transmission, calibrated to South African HIV data using a Bayesian-melding-inspired approach, to study the potential transmission effects of HIV prevention interventions. We retain an interest in this area. “These are our hope,” said Michal Mina, assistant professor of epidemiology at Harvard T.H. Because antimicrobial use affects not only the individual who uses it, but also the pathogen population, much of our effort has been to define the effects of antimicrobial use at the population level, focusing on S. pneumoniae drug resistance, resistance in hospital-acquired infections, among others. With Jeff Shaman, we correctly projected that no winter 2010 wave of the pandemic would likely occur in the US, apart from a small one in the Southeast. In July 2014 16 scientists cofounded the Cambridge Working Group, which called for PPP experiments to be curtailed pending a risk-benefit assessment, a call that garnered over 300 signatures from prominent scientists and others. Dr. Michael Mina, MD, PhD is an Assistant Professor of Epidemiology at Harvard T. H. Chan School of Public Health and a core member of the Center for Communicable Disease Dynamics (CCDD). We have shown age-specific patterns of gene presence for the pilus and some other proteins suggestive of immune selection. A 2015 debate on the topic at the Cambridge Center for the Study of Existential Risk with Derek Smith lays out the major issues. Development of new methods for infectious disease data analysis. Recent efforts have included an outline of the calculations that should enter such an assessment (with Tom Inglesby) and pieces for more general readers including a debate in Nature Reviews Microbiology and an opinion piece Scientific American. Harvard T.H. Nick Croucher, Bill Hanage and I led analysis of 616 pneumococcal genomes from Massachusetts, collected 2001-7 by the SPARC project led by Jonathan Finkelstein and Grace Lee with Steve Pelton. An unrelated collaboration with the American Bible Society had caused his group to collect well-being data from thousands of participants in January and then in June. Antimicrobial resistance in S. pneumoniae. epidemiology, former Research Fellow at Harvard Medical School. Chan School of Public Health and The World from PRX & GBH Tuesday, October 13, 2020 The COVID-19 death toll has surpassed 200,000 people in the United States, and areas of the country continue to see surges. The seasonality of infectious diseases is one of the oldest observations in medicine, yet the mechanisms underlying seasonality are poorly understood. In a mid-day conference call on Friday, March 20, epidemiologist Marc Lipsitch, a professor at the Harvard T.H. Dr. Harvey Risch, a professor of epidemiology at the Yale School of Public Health and Yale School of Medicine joined Fox News host Laura Ingraham Wednesday. Academic Departments, Divisions and Centers. By any measure of human health or well-being, this year has been catastrophic. With Gabriela Gomes we have been exploring the consequences of modeling vaccines as shifting the dose-response curve to the right. Caroline Buckee, associate professor of epidemiology, Department of Epidemiology, Harvard T.H. Bill Hanage, an associate professor of epidemiology at the Harvard T.H. Tobias Kurth, MD, ScD. Dr. Marc Lipsitch is a Professor of Epidemiology at the Harvard School of Public Health with a primary appointment in the Department of Epidemiology and a joint appointment in the Department of Immunology and Infectious Diseases. An exciting collaboration led by Andrew Wargo, including Gabriela and Gael Kurath,  examines this question experimentally using two vaccines against diseases of salmon. In progress are further explorations of the ethical dimensions with Nick Evans. Bill Hanage is an associate professor of epidemiology at the Harvard TH Chan School of Public Health. Want to keep up-to-date on the latest department news? Some of this work is motivated mainly by practical questions in public health (such as vaccine design and intervention targeting), and some is motivated by classical questions in population biology, such as how to explain patterns of coexistence of pathogen strains in space and time. I have a framed photo of Camus … He is additionally an Assistant Professor in Immunology and Infectious Diseases at HSPH and Associate Medical Director in Clinical Microbiology (molecular diagnostics) in the Department of … Harvard epidemiology professor Marc Lipsitch said that “the data from Korea, once analyzed, will be of great global value in helping to understand these important questions.” #AsiaNewsNetwork This immunity is independent of serotype and reduces duration of colonization rather than preventing acquisition. 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